Fellow-Post Doc-Research / Asgharzadeh Lab

Company: Children's Hospital Los Angeles
Location: Los Angeles
Posted on: November 6, 2024

Job Description:

NATIONAL LEADERS IN PEDIATRIC CARERanked among the top 10 pediatric hospitals in the nation, Children's Hospital Los Angeles (CHLA) provides the best care for kids in California.Here world-class experts in medicine, education and research work together to deliver family-centered care half a million times each year. From primary to complex critical care, more than 350 programs and services are offered, each one specially designed for children.The CHLA of the future is brighter than can be imagined. Investments in technology, research and innovation will create care that is personal, convenient and empowering. Our scientists will work with clinical experts to take laboratory discoveries and create treatments that are a perfect match for every patient. And together, CHLA team members will turn health care into health transformation.Join a hospital where the work you do will matter-to you, to your colleagues, and above all, to our patients and families. The work will be challenging, but always rewarding.It's Work That Matters.OverviewPurpose Statement/Position Summary: The Asgharzadeh Lab is seeking a highly talented and self-motivated computational biologist for a post-doctoral position. Our team integrates experimental and computational methodologies to study the tumor microenvironment of childhood cancers (neuroblastoma and other solid tumors) to uncover the molecular mechanisms of chemotherapy and immunotherapy resistance. We use cutting-edge technologies such as highly multiplexed antibody-based imaging (Akoya Phenocycler), spatial transcriptomics (seqFISH), and single-cell omics, combined with innovative computational approaches, to delineate the mechanisms underlying chemo and immunotherapy resistance. Prospective postdocs will have the opportunity to work on a funded NCI project and collaborate with multiple national groups working on characterizing spatial features of adult and pediatric cancers. The Research Post Doc Fellow is in training to help develop the academic knowledge and research fundamentals, teaching expertise and administrative experience necessary to be an exemplary researcher. Perform laboratory work and conduct research activities independently or in collaboration with the Principal Investigator. Publish results in scientific manuscripts and research publications. Participate in seminars, meetings, trainings and other educational sessions.Key Responsibilities (include but are not limited to):

• Establish pipelines and existing algorithms to characterize the tumor microenvironment using single-cell genomics data from tumors obtained pre and post therapy.
• Create machine learning-based pipelines to identify changes in spatial omics patterns of gene and protein expression in tumor tissues.
• Contribute to the development, execution, and optimization of advanced computational biology methods for the integrative analysis of genomics data.
• Collaborate with molecular and cell biologists to investigate the molecular bases of cancer and metastasis.
• Present research findings at national and international scientific conferences and draft manuscripts for publication.Minimum Qualifications/Work Experience:
  • Exposure to and/or experience in research in a healthcare environment preferred.
  • Experience with the integrative analysis and interpretation of multiplexed imaging, spatial transcriptomics, and single-cell omics data.
  • Proficiency with image processing, machine learning, and deep learning techniques.
  • Proficiency in scripting environments for statistics and data analysis (R/Bioconductor, Python) and familiarity with command line interfaces and the Linux operating system.
  • Familiarity with standard bioinformatic analyses, including bulk and single-cell genomics.
  • Candidates should be scientifically curious and able to work independently.Education/Licensure/Certification: MD and/or PhD, or equivalent doctoral degree. Candidates with a PhD in bioengineering, computer science, physics, mathematics, statistics, cell and molecular biology, biotechnology, or any related field in the life sciences with strong expertise in computational biology and bioinformatics highly preferred.Pay Scale Information$29,640.00-$80,196.00CHLA values the contribution each Team Member brings to our organization. Final determination of a successful candidate's starting pay will vary based on a number of factors, including, but not limited to education and experience within the job or the industry. The pay scale listed for this position is generally for candidates that meet the specified qualifications and requirements listed on this specific job description. Additional pay may be determined for those candidates that exceed these specified qualifications and requirements. We provide a competitive compensation package that recognizes your experience, credentials, and education alongside a robust benefits program to meet your needs. CHLA looks forward to introducing you to our world-class organization where we create hope and build healthier futures.Children's Hospital Los Angeles (CHLA) is a leader in pediatric and adolescent health both here and across the globe. As a premier Magnet teaching hospital, you'll find an environment that's alive with learning, rooted in care and compassion, and home to thought leadership and unwavering support. CHLA is dedicated to creating hope and building healthier futures - for our patients, as well as for you and your career!CHLA has been affiliated with the Keck School of Medicine of the University of Southern California since 1932.At Children's Hospital Los Angeles, our work matters. And so do each and every one of our valued team members. CHLA is an Equal Employment Opportunity employer. We consider qualified applicants for all positions without regard to race, color, religion, creed, national origin, sex, gender identity, age, physical or mental disability, sexual orientation, marital status, veteran or military status, genetic information or any other legally protected basis under federal, state or local laws, regulations or ordinances.Qualified Applicants with disabilities are entitled to reasonable accommodation under the California Fair Employment and Housing Act and the Americans with Disabilities Act. Please contact CHLA Human Resources if you need assistance completing the application process.Diversity inspires innovation. Our experiences, perspectives and backgrounds allow us to better serve our patients and create a strong community at CHLA.
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Keywords: Children's Hospital Los Angeles, Lakewood , Fellow-Post Doc-Research / Asgharzadeh Lab, Healthcare , Los Angeles, California