Medicinal Chemistry - Principal Scientist/Senior Principal Scientist
Company: Society of Exploration Geophysicists
Location: San Diego
Posted on: November 12, 2024
Job Description:
Light Horse Therapeutics is a small molecule drug discovery
company based in San Diego, employing tools from chemical and
computational biology, in conjunction with precision genome editing
methods to identify functional/ligandable sites on high value
oncology protein targets for therapeutic intervention. Light Horse
therapeutics was founded by leading academics Brian Liau (Harvard),
Ben Cravatt (Scripps) and Nathanael Gray (Stanford) with initial
financial backing from Versant Ventures and Mubadala Capital.Light
Horse Therapeutics is seeking a talented, motivated, and creative
Principal / Senior Principal Scientist to join the Medicinal
Chemistry group. The candidate will contribute to strategy and
implementation in discovery programs for high value, challenging
oncology targets. The candidate will also have the opportunity to
drive discovery programs and contribute broadly to building an
understanding of novel target biology in a dynamic start-up
environment that employs cutting-edge tools in functional genomics
and proteomic technologies.Job Description:
- Lead chemistry for multiple early projects and drive the
Design, Make, Test, Analyze cycle
- Plan, prioritize and implement synthetic and medicinal
chemistry strategies to achieve project goals
- Effectively manage external chemistry resources at partner
CROs, including target selection and prioritization, synthetic
planning and troubleshooting, and routine in vitro ADME and PK
studies
- Collaborate with functional leads - e.g., computational
chemistry, biology, proteomics, and structural research - to design
appropriate flowcharts
- Analyze data sets and develop SAR using in-house and commercial
in silico tools and communicate results in formal and informal
settings
- Apply advanced medicinal chemistry principles to design high
quality compounds, considering multiple parameters in parallel -
e.g., potency, selectivity, SBDD, ADME/PK, physicochemical
properties
- Provide clear communication of the medicinal chemistry strategy
to cross-functional colleagues, scientific leadership and external
collaborators
- Lead the preparation of patent applications and scientific
publications as appropriate
- The individual should be scientifically creative and driven by
a willingness to embrace innovation and an eagerness to challenge
and meet aggressive timelines
- This position does not require laboratory workRequired
Qualifications:
- PhD in in organic chemistry, in addition to 6+ years of
medicinal chemistry experience in the biopharmaceutical
industry
- High levels of competence in all aspects of modern synthetic
chemistry, including single compound synthesis, small parallel
arrays, purification methods and analytical characterization
- Significant experience and successful implementation of
independent synthetic route design and problem solving
- Familiarity with a variety of biochemical, biophysical, and
cellular assays and ability to interpret data derived from such
assays
- Understanding of correlations between compound structure,
properties, and ADME and ability to optimize multiple
parameters
- Proven ability to work well with others in a dynamic and highly
collaborative environment
- Excellent communication skills are required, particularly the
ability to effectively present work and ideas and contribute to
team discussions.We offer a competitive total compensation package,
as well as working in a supportive team environment. The
anticipated salary range for candidates who will work in San Diego,
CA is $150,000 to $230,000. The final salary offered to a
successful candidate will be dependent on several factors that may
include but are not limited to the type and length of experience
within the job, type and length of experience within the industry,
education, etc.
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Keywords: Society of Exploration Geophysicists, Lakewood , Medicinal Chemistry - Principal Scientist/Senior Principal Scientist, Other , San Diego, California
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